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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN3 All Species: 32.42
Human Site: Y447 Identified Species: 71.33
UniProt: P51790 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51790 NP_001820.2 818 90966 Y447 V I A F P N P Y T R L N T S E
Chimpanzee Pan troglodytes XP_001154165 791 87957 Y420 V I A F P N P Y T R L N T S E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848379 760 84902 E409 F N D C G A L E S S Q L C D Y
Cat Felis silvestris
Mouse Mus musculus P51791 818 90851 Y447 V I A F P N P Y T R L N T S E
Rat Rattus norvegicus P51792 818 90837 Y447 V I A F P N P Y T R L N T S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506627 818 90891 Y447 V I A F P N P Y T R L N T S E
Chicken Gallus gallus XP_420400 866 96559 Y447 V I A F P N P Y T R L N T S E
Frog Xenopus laevis NP_001083736 791 88122 Y420 I I A F P N P Y T R F N T S Q
Zebra Danio Brachydanio rerio XP_001923503 874 97004 Y451 I V A F P N P Y T R Q N T S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92943 792 87043 A433 F F N T Q D D A I R N L F S A
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 S419 C V K N D N T S T F S H R L C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.3 N.A. 72.8 N.A. 99.5 99.3 N.A. 98.6 91.8 89 82.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 94.9 N.A. 83.1 N.A. 99.7 99.7 N.A. 99.3 93.4 92.5 88.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 0 N.A. 100 100 N.A. 100 100 80 80 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 6.6 N.A. 100 100 N.A. 100 100 93.3 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.3 30.6 N.A.
Protein Similarity: N.A. N.A. N.A. 49.5 50.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 73 0 0 10 0 10 0 0 0 0 0 0 10 % A
% Cys: 10 0 0 10 0 0 0 0 0 0 0 0 10 0 10 % C
% Asp: 0 0 10 0 10 10 10 0 0 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 64 % E
% Phe: 19 10 0 73 0 0 0 0 0 10 10 0 10 0 0 % F
% Gly: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 19 64 0 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 10 0 0 0 55 19 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 10 10 0 82 0 0 0 0 10 73 0 0 0 % N
% Pro: 0 0 0 0 73 0 73 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 10 0 0 0 0 0 19 0 0 0 10 % Q
% Arg: 0 0 0 0 0 0 0 0 0 82 0 0 10 0 0 % R
% Ser: 0 0 0 0 0 0 0 10 10 10 10 0 0 82 0 % S
% Thr: 0 0 0 10 0 0 10 0 82 0 0 0 73 0 0 % T
% Val: 55 19 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 73 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _